. 2021 Aug 10;7(8):e07752. doi: 10.1016/j.heliyon.2021.e07752

Table 2.

Summary of stability results of Pan and Ami in human plasma using the proposed LC- MS/MS method.

Stability Term	QC sample	Pan				Ami
Stability Term	QC sample	QC Conc (μgmL⁻¹)	Mean recovered Conc (μgmL⁻¹)	% Nominal ±SD	CV%	QC Conc (μgmL⁻¹)	Mean recoverd Conc (μgmL⁻¹)	% Nominal ±SD	CV%
Short term (after 4hr) Bench top stability or	LQCL	0.030	0.0296	98.67 ± 0.32	1.08	0.003	0.0029	96.67 ± 0.03	0.88
	MQC	1.600	1.5978	99.86 ± 0.43	0.21	0.030	0.0293	97.67 ± 0.62	2.13
	HQC	3.000	2.9847	99.49 ± 7.79	0.26	0.075	0.0746	99.46 ± 0.30	0.41
Long term (after 20days)	LQC	0.030	0.0289	96.33 ± 0.16	0.55	0.003	0.0030	100.00 ± 0.02	0.59
	MQC	1.600	1.5837	98.98 ± 9.38	0.59	0.030	0.0290	96.67 ± 0.42	1.44
	HQC	3.000	2.9466	98.22 ± 50.71	1.72	0.075	0.0741	98.80 ± 0.56	0.76
Auto-sampler (post-preperative stability)	LQC	0.030	0.0298	99.38 ± 0.20	0.67	0.003	0.0029	97.29 ± 0.01	0.36
	MQC	1.600	1.5933	99.58 ± 7.90	0.50	0.030	0.0292	97.33 ± 0.20	0.69
	HQC	3.000	2.9901	99.67 ± 3.22	0.11	0.075	0.0738	98.40 ± 0.42	0.56
Freeze- thaw (after three cycles)	LQC	0.030	0.0297	99.11 ± 0.36	1.23	0.003	0.0029	99.33 ± 0.05	1.80
	MQC	1.600	1.5961	99.75 ± 4.81	0.3	0.030	0.0293	97.66 ± 0.18	0.63
	HQC	3.000	2.9932	99.77 ± 5.8	0.19	0.075	0.0741	98.80 ± 0.48	0.65
Dry extract stability	LQC	0.030	0.0287	95.66 ± 1.49	1.55	0.003	0.0028	91.74 ± 1.32	1.44
	MQC	1.600	1.5781	98.63 ± 0.18	0.19	0.030	0.0280	91.74 ± 2.62	2.68
	HQC	3.000	2.9381	97.93 ± 1.05	1.07	0.075	0.0743	96.79 ± 0.22	0.23
Stock stability solution	Pan			97.26	0.51
	Ami			96.90	0.63
	Omp (IS)			97.17	0.52
	Dot (IS)			97.22	0.31