. 2021 Aug 10;7(8):e07752. doi: 10.1016/j.heliyon.2021.e07752

Table 3.

Pharmacokinetics parameters results of Pan and Ami in Treatment A and Treatment B.

Pharmacokinetic parameters^∗	n = 6
	Treatment A			Treatment B
	Mean	SD	CV%	Mean	SD	CV%
	Formulation (Pan)

Pan = 2.05 mg/kg

k _el (hr⁻¹)	0.17	0.05	26.69	0.29	0.01	3.49
t_{1/2 el} (hr)	4.12	1.00	24.32	2.43	0.08	3.41
AUC _0-24 (μg.hr/mL)	2.60	0.86	33.10	3.74	0.46	12.31
AUC _0–∞ (μg.hr/mL)	2.66	0.86	32.32	3.77	0.46	12.19
AUMC_0–∞(μg.hr²/mL)	7.78	0.92	11.83	12.62	1.25	9.90
T _max (hr)	0.50	0	0	0.39	0.10	25.71
C _{max (}μg/mL)	2.22	1.57	70.65	1.30	0.23	17.71
V_d/F (L/kg)	5.02	1.81	36.08	1.92	0.30	15.65
CL/F (ml/min/kg)	13.67	3.72	27.22	9.17	1.14	12.43
K _abs (hr⁻¹)	7.90	0.56	7.15	11.20	0.00	0.00
t _{1/2 abs} (hr)	0.09	0.01	7.42	0.06	0.31	14.63
MRT _0-∞ (hr)	3.15	1.09	34.65	3.35	0.13	3.68
	Formulation (Ami)

Ami = 0.51 mg/kg

k _el (hr⁻¹)	0.03	0.01	16.45	0.04	0.01	20.97
t_{1/2 el} (hr)	21.59	3.34	15.47	17.50	3.44	19.65
AUC _0-24 (μg.hr/mL)	0.06	0.02	36.36	0.05	0.01	16.98
AUC _0–∞ (μg.hr/mL)	0.10	0.02	21.42	0.09	0.02	25.84
AUMC_0–∞ (μg.hr²/mL)	2.38	0.45	18.75	2.22	1.00	45.01
T _max (hr)	0.22	0.10	43.11	0.72	0.67	93.32
C _{max (}μg/mL)	0.03	0.01	40.41	0.01	0.002	23.81
V_d/F (L/kg)	166.37	52.45	31.53	145.87	31.22	21.40
CL/F (mL/min/kg)	87.95	19.74	22.45	97.11	21.85	22.50
K _abs (hr⁻¹)	12.86	7.17	55.79	3.41	2.02	59.08
t _{1/2 abs} (hr)	0.08	0.06	82.30	0.31	0.28	89.67
MRT _0-∞ (hr)	25.49	6.92	27.16	24.46	4.83	24.47

^∗

Parameters are K _el: Elimination rate constant, t_{1/2, el}:Elimination half-life of drug, AUC_0–24: Area under the curve up to 24 h, AUC_0-∞: Area under the curve up to infinity, AUMC_0-∞:Area under the first moment curve up to infinity, T _max: Maximum plasma concentration, C _max: maximum plasma concentration, V_d: Apparent volume distribution of drug, F: bioavailability of drug, CL: Clearance,. K _abs: Absorption rate constant, t _{½ abs}: Absorption half-life, MRT_0–∞: Mean residual time up to infinity, (n = 6, no of rabbit in each group).