Table 4.
Summary of ANOVA test for pharmacokinetic parameters following the administration of Treatment A and Treatment B.
| Variables | DF | SS | MS | F -calculated | P-value | F-Critical | |
|---|---|---|---|---|---|---|---|
|
Formulation (Pan) |
|||||||
| kel | 1 | 0.040659 | 0.040659452 | 47.48512287 | 0.0000424093 | 4.964602701 | S |
| t1/2 el | 1 | 9.990031718 | 9.990032 | 24.57396416 | 0.000572387 | 4.964602701 | S |
| AUC 0-24 | 1 | 1.942226 | 1.942225753 | 4.100431315 | 0.00785936 | 4.964602701 | NS |
| AUC 0–∞ | 1 | 1.8542499 | 1.8542499 | 3.898 | 0.120 | 4.964602701 | NS |
| AUMC0–∞ | 1 | 4433.437 | 4433.437033 | 3.414577326 | 0.094375974 | 4.964602701 | NS |
| T max | 1 | 0.009263 | 0.009262963 | 2.5 | 0.1449276 | 4.964602701 | NS |
| C max | 1 | 4.014852279 | 4.014852279 | 5.215636 | 0.048 | 4.964602701 | S |
| Vd/F | 1 | 28.80014 | 28.80014377 | 21.39541761 | 0.000942605 | 4.964602701 | S |
| CL/F | 1 | 60.76912 | 60.769122 | 10.03318166 | 0.010029824 | 4.964602701 | S |
| K abs | 1 | 32.66357 | 32.66356532 | 87.93778631 | 2.85561E-06 | 4.964602701 | S |
| t 1/2 abs | 1 | 0.0010279 | 0.0010279 | 48.039 | 0.002 | 4.964602701 | S |
| MRT |
1 |
0.128107 |
0.128106881 |
0.265808202 |
0.617362756 |
4.964602701 |
NS |
| Formulation (Ami) | |||||||
| k el | 1 | 0.000195 | 0.0001952 | 4.792314491 | 0.053413976 | 4.964602701 | NS |
| t1/2 el | 1 | 25.09465 | 25.094651 | 2.184361437 | 0.213489081 | 4.964602701 | NS |
| AUC 0-24 | 1 | 0.00016 | 0.0001598 | 0.68422833 | 0.42743197 | 4.964602701 | NS |
| AUC 0–∞ | 1 | 0.000214 | 0.0002139 | 0.565413106 | 0.469415754 | 4.964602701 | NS |
| AUMC0–∞ | 1 | 0.082142 | 0.0821424 | 0.171936615 | 0.687151419 | 4.964602701 | NS |
| T max | 1 | 0.705966 | 0.705966 | 4.106494527 | 0.070219993 | 4.964602701 | NS |
| C max | 1 | 0.001051 | 0.001051 | 23.53372713 | 0.000670214 | 4.964602701 | S |
| Vd/F | 1 | 1259.87 | 1259.8769 | 0.845427289 | 0.379494236 | 4.964602701 | NS |
| CL/F | 1 | 251.8523 | 251.85225 | 0.726044291 | 0.414109041 | 4.964602701 | NS |
| K abs | 1 | 267.7367 | 267.73671 | 12.05532912 | 0.006000196 | 4.964602701 | S |
| t 1/2 abs | 1 | 0.168785 | 0.1687854 | 9.659051581 | 0.011100273 | 4.964602701 | S |
| MRT | 1 | 3.223482 | 3.2234821 | 0.113052778 | 0.743643785 | 4.964602701 | NS |
DF: Degree of freedom, SS: Sum of Squares, MS: Mean of Squares, NS: Non significant difference, S: Significant difference.