Fig. 1.

Schematic diagram of wild-type and mutated forms of the type-II transmembrane protein BRI₂ as originally proposed by Vidal et al. (2004). a Processing by pro-protein convertases (PCs) releases a 23 amino acid peptide (Bri₂-23). Processing by ADAM10 in the ectodomain of BRI₂ releases the BRICHOS domain and an N-terminal fragment (NTF). Further processing of the membrane bound fragment by SPPL2a/SPPL2b releases an intracellular domain (ICD) and a secreted low molecular weight C-terminal peptide (C). Disulfide bonded loops in the BRICHOS domain and in the carboxy-terminus of BRI₂ are indicated. b Processing by PCs of the mutated precursor proteins releases the 34 amino acid ABri and ADan peptides