Fig. 6.

Ultrastructure of hippocampal parenchymal amyloid deposits. a Bundles of fibrillar amyloid are seen within microglial cells. Swollen astroglial processes containing glial filaments are seen in close proximity to the amyloid deposit as well as degenerating neuronal processes and dystrophyc neurites. b Neurons adjacent to amyloid deposits, particularly in the hippocampus, showed morphological evidence of degeneration, and often ultrastructural features of cellular death. Transmission electron microscopy (TEM) of an 18-month-old Tg-FDD mouse. Amyloid (A), dystrophic neurites (DN), microglia (M), neurons (N), and astrocytic processes (AS) were identified