Mean (N= 6 / group; ±SEM) A) body temperature, and B) activity rate, after vapor inhalation of THC (100 mg/mL) for 40 minutes. C) mean (N=5 per strain / dose combination; ±SEM) plasma THC concentrations after vapor inhalation of THC (50, 100 mg/mL) for 40 minutes. Open symbols indicate a significant difference from both PG (within respective pre-treatment) at a given time-point and the within-treatment baseline, while shaded symbols indicate a significant difference from the baseline only. A significant difference from all other treatment conditions at a given time point is indicated with &, a difference between strains for a given time and inhalation condition with *, a difference between inhalation concentrations collapsed across strain with $ and a difference across time, collapsed across strain, with #.