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. 2021 Aug 10;10:e71220. doi: 10.7554/eLife.71220

Figure 3. Dimerization of TMEM120A.

Figure 3.

(a) Extensive dimerization interactions occur in three boxed regions: the coiled coil domain (CCD) (box 1), the re-entrant loop (box 2), and the external side of transmembrane domain (TMD) (box 3). (b) Zoomed-in view of dimerization interactions at CCD. Residues that participate in the inter-subunit contact are W16, L19, F23, I26, H30, Y33, L37, L40, L43, I51, L58, and L61 in CC1, and L83, M87, L93, F94, M97, Y100, and L101 in CC2. (c) Zoomed-in view of dimerization at the re-entrant loop. Shown in the left panel are the inter-subunit hydrogen bonding interactions between R178 side chain and the carbonyl oxygen atoms of S110, L111, and V112, between Y129 side chain and the carbonyl oxygen of L113, and between the side chains of E132 and N115. Shown in the right panel are the inter-subunit hydrophobic contacts between the two re-entrant loops and between the re-entrant loop and transmembrane helices (TMs) 1-2 of the neighboring subunit. (d) Zoomed-in view of the inter-subunit hydrophobic contacts between the two TMDs.