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. 2021 Aug 10;10:e71220. doi: 10.7554/eLife.71220

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© 2021, Xue et al

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Figure 4. — (a) Structures of the 6-TM α-barrel transmembrane domains (TMDs) from TMEM120A (TMs 1–6, left) and ELOVL7 elongase (TMs 2–7, right). Coenzyme A (CoA) in TMEM120A and 3-keto acyl-CoA in ELOVL7 are rendered as sticks. (b) Structural comparison between the 6-TM barrels from TMEM120A (orange) and ELOVL7 (blue) in side view (left) and bottom view (right). HxxHH motif in ELOVL7 is colored in cyan. The WVFHH sequence of TMEM120A at the equivalent location is colored in yellow.