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. 2021 Aug 11;10:e68371. doi: 10.7554/eLife.68371

Figure 5. STAT1KO mice are prone to develop spontaneous colitis.

Figure 5.

(A) Representative colon gross anatomy of WT and STAT1 KO mice. (B) Representative histology of WT and STAT1 KO colons, stained with H&E (scale bar = 200 μm). (C) Histopathologic scores of WT and STAT1 KO colons. Scoring was performed for severity and extent of inflammatory cell infiltrates and for epithelial changes (hyperplasia [hyperpl] and goblet cell loss [GC loss]) (n = 5 for WT, n = 6 for STAT1 KO) *p<0.05, **p<0.01 by Mann−Whitney U test. (D) Bacterial leakage (CFU/organ) into liver (LIV), mesenteric lymph nodes (MLN) and spleen (SPL), as described in materials and methods (n = 5 for WT, n = 7 for STAT1 KO). (E) Colon length after 7 days of DSS treatment in drinking water (n = 4 for WT, n = 7 for STAT1 KO) **p<0.01 by Student’s t-test. (F) Representative histology of WT and STAT1 KO colons, stained with H&E, after 7 days of DSS treatment (scale bar = 200 μm). Each symbol represents an individual animal (C–E).