Extended Data Fig. 6. Addressing cell cycle and complexity covariates by the Perturb-CITE-seq model and impact of targeting vs. non-targeting guides.

a, Estimated Multiplicity of infection (MOI). Distribution of cells (%, y axis) at different estimated MOI (x axis) in each experimental condition (color legend) as determined from the guide dictionary (Methods). b,c, Improved model fit following accounting for cell state as a covariate. Pearson correlation (color bar) between the residuals from the linear model fit for each regulated feature (columns) from models learned without (b) or with (c) cell state covariates accounting for the cell cycle and cell complexity.