FIGURE 4.

Subunit exchange between Rel dimers at 37 °C. ESI‐MS time‐course of subunit exchange between p50‐1/p65‐1 (white and black circles) and p50‐2/p65‐2 (white circles with tails and black circles with tails) RHD heterodimers. The panel insert shows the relative populations of each species from 0‐1000 minutes. Note that values obtained for the p50‐1/p65‐1 and p50‐2/p65‐2 heterodimeric species have been averaged to generate the decay curve, and that values obtained for the p50‐1/p65‐2 and p50‐2/p65‐1 heterodimeric species have been averaged to generate the corresponding growth curve. ESI, electrospray ionization; MS, mass spectrometry; RHD, Rel homology domain