Table 1.
Effect of naringin, hesperidin, and their combination on serum biochemical parameters related to liver function in diclofenac-administered rats.
| Parameter | Normal control | Diclofenac | Diclofenac+naringin | Diclofenac+hesperidin | Diclofenac+naringin+hesperidin |
|---|---|---|---|---|---|
| ALT (U/L) | 48.0 ± 1.34c | 62.00 ± 0.89a | 58.83 ± 0.94ab | 51.00 ± 0.63c | 55.50 ± 2.4b |
| AST (U/L) | 138.20 ± 5.11b | 244.00 ± 30.44a | 163.83 ± 16.31b | 141.00 ± 6.76b | 136.67 ± 8.46b |
| LDH (U/L) | 366.00 ± 51.42c | 786.00 ± 18.33a | 615.66 ± 65.19b | 580.66 ± 14.53b | 669.00 ± 1.79b |
| ALP (U/L) | 193.66 ± 18.92c | 329.33 ± 33.80a | 259.83 ± 9.10b | 270.17 ± 21.05ab | 226.33 ± 10.83bc |
| GGT (U/L) | 5.30 ± 1.10b | 17.0 ± 0.80a | 5.00 ± 1.00b | 7.00 ± 1.00b | 4.50 ± 0.80b |
| Albumin (g/dL) | 3.0 ± 0.04a | 3.03 ± 0.02a | 2.95 ± 0.09a | 3.02 ± 0.05a | 2.90 ± 0.04a |
| Bilirubin (mg/dL) | 0.30 ± 0.04b | 0.50 ± 0.04a | 0.33 ± 0.02b | 0.30 ± 0.04b | 0.35 ± 0.05b |
Data are expressed as the mean ± SE. Number of animals in each group is six. Means, which share different superscript symbols in the same row, are significantly different at p < 0.05.