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. 2021 Feb 22;28(7-8):456–468. doi: 10.1038/s41434-021-00223-3

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© The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Representative RNAscope images showed Cas9 mRNA expression, shown in violet, and cell nuclei, shown in blue, in various CNS regions in the Cas9 knock-in mice (a–k) and the age-matched wild-type mice (l–v): a sagittal section of the whole brain (a and l), olfactory bulb (b and m), cortex (c and n), hippocampus (d and o), corpus callosum (e and p), substantia nigra pars compacta (f and q), a full transverse section of the spinal cord (g and r), thalamus (h and s), cerebellum (i and t), gray matter area of the ventral spinal cord (j and u), and white matter area of the spinal cord (k and v). All scale bars are 50 µm.