Fig. 2. Prostate Cancer Diagnosis and Data Collection Workflows.

a Schema of typical workflow for diagnosis of prostate cancer from H&E-stained needle biopsies adopted by pathologists in the hospital. b Workflow after introduction of our tool for advance IHC requesting. The tool scans the H&E slide and requests IHC automatically, which is processed immediately after the H&E slide is scanned. The introduction of the IHC tool speeds up sign out of the case report. c Datasets used for training, testing and validating the network. The dataset used for training and testing the network is a snapshot of standard clinical decisions made independently by pathologists. The validation dataset was annotated retrospectively and blindly to the archived data original labels. The procedure replicates the decision-making that occurs in the hospital.