Table 4.
Presynaptic receptors on central and peripheral noradrenergic neurones identified by Manfred Göthert. For presynaptic 5-HT receptors, see text and Tables 1 and 2
| Effect | Modulator (receptor) | Tissue | References | |
|---|---|---|---|---|
| Inhibition | Noradrenaline (α2) | Basic evidence | Human saphenous vein, pulmonary artery, corpus cavernosum; rabbit heart, aorta, pulmonary artery; rat cerebral cortex | Göth ert et al. (1984), Hentrich et al. (1986), Molderings et al. (1989b); Göthert (1977), Docherty et al. (1982); Göthert et al. (1979b), Fink and Göthert (1993b) |
| α2A-subtype | Human right atrium, saphenous vein; rabbit pulmonary artery | Molderings and Göthert (1995a), Molderings et al. (2000a, 2003a), Brüss et al. (2003) | ||
| Imidazoline (LPA1 and/or LPA3?) | Human atrium, pulmonary artery; rabbit aorta, pulmonary artery; guinea-pig pulmonary artery; rat aorta and vena cava; rat pheochromocytoma cell line PC12 | Likungu et al. (1996), Molderings et al. (1997); Docherty et al. (1982), Göthert and Molderings (1991), Molderings et al. (1991), Molderings and Göthert (1995b); Molderings and Göthert (1999); Molderings and Göthert (1998); Molderings et al. (2002a) | ||
| Acetylcholine (mACh) | Rabbit heart, pulmonary artery | Göthert (1977), Molderings et al. (2006) | ||
| Histamine (H3) | Human cerebral cortex, saphenous vein; pig retina vasculature; rat cerebral cortex; mouse cerebral cortex | Schlicker et al. (1994c), Molderings et al. (1992a); Schlicker et al. (1990); Schlicker et al. (1989c, 1992b, 1994c), Fink et al. (1994b); Schlicker et al. (1992b, c, 1994b, c), Kathmann et al. (1994), Nickel et al. (2001) | ||
| Opioid μ and δ | Rat cerebral cortex | Göthert and Wehking (1980), Göthert et al. (1979b) | ||
| Somatostatin | Rat hypothalamus | Göthert (1980b) | ||
| Prostaglandin E2 (EP3) | Human right atrium, pulmonary artery, saphenous vein, corpus cavernosum | Molderings et al. (1992b, 1994a, 1998a) | ||
| Cannabinoid (CB1) | Human, guinea-pig hippocampus; guinea-pig vessels | Schlicker et al. (1997b), Kathmann et al. (1999); Schultheiß et al. (2005) | ||
| Facilitation | Noradrenaline, adrenaline (β2) | Basic evidence | Human pulmonary artery, saphenous vein; rat vena cava | Göthert and Hentrich(1985), Hentrich et al. (1985), Molderings et al. (1988b); Göthert and Kollecker (1986) |
| via AT1 receptors | Human saphenous vein; rat vena cava, pithed rat | Molderings et al. (1988b); Göthert and Kollecker (1986), Schlicker et al. (1988c) | ||
| Acetylcholine (nACh) | Rabbit heart | Göthert (1974) | ||
| Glutamate | (NMDA) | Human, guinea-pig, rat cerebral cortex | Fink et al. (1992b), Kathmann et al. (1999), Fink et al. (1990b) | |
| (AMPA) | Human, rat cerebral cortex | Fink et al. (2000, 2002b) | ||
| Angiotensin II (AT1) | Human pulmonary artery, saphenous vein; rabbit heart | Molderings et al. (1988b); Göthert (1977) | ||
| ACTH (MC2) | Rabbit pulmonary artery | Göthert (1981, 1984), Göthert and Hentrich (1984) | ||
| Prostaglandin D2 (DP) | Human right atrium, pulmonary artery, saphenous vein, corpus cavernosum | Molderings et al. (1992b, 1994a, 1998a) | ||