Table 2.
Results from cohort studies reporting cumulative incidence of subsequent fracture
| Comparison | Cumulative incidence of subsequent fracture | P-value | |
|---|---|---|---|
| No-FLS | FLS | ||
| Pre-FLS vs. post-FLS | |||
| Huntjens et al. [19] | 9.9% | 6.7% | P=0.001* |
| Amphansap et al. [21] | 30.0% | 0.0% | P<0.0001* |
| Axelsson et al. [22] | 8.4% | 8.3% | P=0.85 |
| Hawley et al. [23] | NA | 4.2% | NA |
| Bachour et al. [1] | 18.0% | 8.2% | P=0.004* |
| Davidson et al. [24] | 19.1% | 10.5% | P=0.013* |
| Singh et al. [26] | 1.8% | 3.0% | P=0.667 |
| Wasfie et al. [27] | 25.0% | 15.0% | P=0.01* |
| González-Quevedo et al. [28] | 3.6% | 4.6% | P=0.50 |
| Shin et al. [29] | 5.4% | 1.9% | P=0.004* |
| Hospital with FLS vs. hospital without FLS | |||
| Huntjens et al. [30] | 6.8% | 6.7% | Time-dependent** |
| Nakayama et al. [31] | 16.8% | 12.2% | NR |
| Pre-FLS vs. post-FLS and hospital with FLS vs. hospital without FLS | |||
| (a) Inderjeeth et al. [12] | 18.3% | 8.1% | P<0.05* |
| (b) Inderjeeth et al. [12] | 17.3% | 8.1% | NS |
| (a) Axelsson et al. [32] | 12.9% | 5.9% | P<0.001* |
| (b) Axelsson et al. [32] | 9.0%# | 8.0%# | NR |
NA not applicable, NR not reported, NS not significant, FLS fracture liaison service, vs. versus
*Statistical significant P<0.05
**Significantly lower subsequent fracture from fifteen months onward
(a) Study compared pre-FLS to post-FLS care
(b) Study compared hospitals with and without FLS
#Calculated based on available data