Figure 1: Narrow-sense heritability (${\mathit{h}}_{\mathit{S}\mathit{N}\mathit{P}}^2$) estimates of drug outcome phenotypes, divided into contributions from large-, moderate- and small-effect size variants.

The horizontal axes represent the different datasets. A) Heritability of height as a positive control for 6 datasets. B) Heritability of 7 pharmacodynamic phenotypes (Clopidogrel: Platelet reactivity; ACE-inhibitor: Cough; Statins: Major Adverse Cardiac Events (MACE); Vancomycin, Gentamicin, Tacrolimus, Cyclosporine: Peak Creatinine). Clopidogrel ($h_{SNP}^2\cong 25\%$) is a positive control. C) Heritability of 5 pharmacokinetic phenotypes (Methotrexate: Adjusted Drug Clearance; Vancomycin, Gentamicin: Drug trough; Tacrolimus, Cyclosporine: Plasma Concentration to Drug Ratio). Error bars represent conventional high density credible intervals for $h_{SNP}^2$.