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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Clin Pharmacol Ther. 2021 Jul 12;110(3):714–722. doi: 10.1002/cpt.2323

Table 1:

Height analyses data and results.

Dataset Clopidogrel Statins Vancomycin Gentamicin Tacrolimus Cyclosporine
Subjects (n) 1,509 4,843 5,227 254 1,180 508

SNPs post-QC (n) 778,986 1,515,824 1,050,868 1,248,133 1,187,219 1,248,265

Female (n, (%)) 328 (21.7) 1,788 (36.9) 2,293 (43.9) 143 (56.3) 449 (38.1) 208 (40.9)

Age (mean, (SD), years) 63.0 (11.1) NA 53.0 (13.6) 43.5 (15.7) 52.3 (12.0) 49.2 (14.2)

Height (mean, (SD), cm) 170.7 (8.8) 172.3 (10.5) 171.7 (10.7) 169.4 (12.2) 172.5 (10.2) 171.5 (10.4)

σg2 18.6 8.6 13.4 33.7 20.0 25.0

hSNP2 0.43 [0.00, 0.85] 0.19 [0.00, 0.42] 0.24 [0.00,0.46] 0.46 [0.00, 0.94] 0.41 [0.00, 0.85] 0.48 [0.00, 0.92]

Large effect variant (prop., (# SNPs)) 0.06 (19) 0.05 (19) 0.04 (17) 0.32 (47) 0.10 (26) 0.21 (42)

Moderate-effect variant (prop., (# SNPs)) 0.21 (215) 0.39 (363) 0.38 (377) 0.34 (302) 0.45 (400) 0.33 (322)

Small-effect variant (prop., (# SNPs)) 0.74 (6,468) 0.55 (4,976) 0.57 (5,079) 0.34 (3,145) 0.46 (4,027) 0.45 (3,620)

SD – Standard Deviation; σg2 – Additive Genetic Variance; hSNP2  - Narrow-sense Heritability, with conventionally calculated high density credible interval shown in brackets. Prop.: Proportion contributed to total hSNP2. NA indicates data not available.