Table 1:
Dataset | Clopidogrel | Statins | Vancomycin | Gentamicin | Tacrolimus | Cyclosporine |
---|---|---|---|---|---|---|
Subjects (n) | 1,509 | 4,843 | 5,227 | 254 | 1,180 | 508 |
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SNPs post-QC (n) | 778,986 | 1,515,824 | 1,050,868 | 1,248,133 | 1,187,219 | 1,248,265 |
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Female (n, (%)) | 328 (21.7) | 1,788 (36.9) | 2,293 (43.9) | 143 (56.3) | 449 (38.1) | 208 (40.9) |
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Age (mean, (SD), years) | 63.0 (11.1) | NA | 53.0 (13.6) | 43.5 (15.7) | 52.3 (12.0) | 49.2 (14.2) |
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Height (mean, (SD), cm) | 170.7 (8.8) | 172.3 (10.5) | 171.7 (10.7) | 169.4 (12.2) | 172.5 (10.2) | 171.5 (10.4) |
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18.6 | 8.6 | 13.4 | 33.7 | 20.0 | 25.0 | |
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0.43 [0.00, 0.85] | 0.19 [0.00, 0.42] | 0.24 [0.00,0.46] | 0.46 [0.00, 0.94] | 0.41 [0.00, 0.85] | 0.48 [0.00, 0.92] | |
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Large effect variant (prop., (# SNPs)) | 0.06 (19) | 0.05 (19) | 0.04 (17) | 0.32 (47) | 0.10 (26) | 0.21 (42) |
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Moderate-effect variant (prop., (# SNPs)) | 0.21 (215) | 0.39 (363) | 0.38 (377) | 0.34 (302) | 0.45 (400) | 0.33 (322) |
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Small-effect variant (prop., (# SNPs)) | 0.74 (6,468) | 0.55 (4,976) | 0.57 (5,079) | 0.34 (3,145) | 0.46 (4,027) | 0.45 (3,620) |
SD – Standard Deviation; – Additive Genetic Variance; - Narrow-sense Heritability, with conventionally calculated high density credible interval shown in brackets. Prop.: Proportion contributed to total . NA indicates data not available.