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Expired breath carbon monoxide, ppm (top panel), and heart rate, bpm (bottom panel), taken before (striped bars) and after (solid bars) administration of cigarettes with normal nicotine content (NNC), intermediate nicotine content (INC), and very low nicotine content (VLNC) during fixed dose sessions. Error bars represent standard error of the mean. ***Indicates statistical significance of p < .001.
