Subjective reactions, characterized as ratio of Positive to Negative Effects, to administration of normal nicotine content (NNC; black bars), intermediate nicotine content (INC; striped bars), and very low nicotine content (VLNC; white bars) during fixed dose sessions, plotted by cigarette choice during the final choice session. Error bars represent standard error of the mean. **Indicates statistical significance of p < .005. Positive to Negative ratio was significantly greater for the NNC cigarette relative to INC and VLNC cigarettes among those who went on to choose the NNC cigarette. Positive to Negative ratio was significantly greater for the INC cigarette relative to VLNC cigarettes among those who went on to choose the INC cigarette. Positive to Negative ratio did not differ between fixed dose cigarettes among those who chose the VLNC cigarette.