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. 2021 Aug 19;4:933. doi: 10.1038/s42003-021-02448-9

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© The Author(s) 2021, last corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Location, microinfusion, and identification of the bilateral fastigial nucleus injected with formaldehyde. FN fastigial nucleus (location identified by using red fluorescent probe-Dil to mark cell membrane and blue DAPI to stain nucleus). b Cerebellar formaldehyde quantified by an in-vitro small animal imaging system (n = 6). FA-1.5 mM: the group of mice microinfused with 1.5 mM formaldehyde; Con PBS-injected group of mice, FA formaldehyde. c Formaldehyde levels in the cerebellum detected by HPLC (n = 6). HPLC high-performance liquid chromatography. d Cellular morphology of the cerebellar neurons detected by using Nissl staining solutions (n = 3). e Cell toxicity of formaldehyde detected by using a CCK-8 kit (n = 6). f Motor behaviors assessed in FA-injected mice by the accelerating rotarod test (n = 10). g Motor functions in FA-injected mice evaluated by the beam walking test (n = 10). h The model of FN impairments results in cerebellar ataxia induced by HU-derived formaldehyde. VL ventrolateral nucleus of the thalamus. Error bars show the mean ± SEM; **p < 0.01; ***p < 0.001.