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. 2021 Aug 19;11:16891. doi: 10.1038/s41598-021-96521-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Involvement of DNA damage signaling in the induction of mRNA expression of CXCL9/10/11 by T-DXd in HER2-positive GC cells. (A) Comparison of mRNA expression (z-score) of CXCL9, CXCL10, and CXCL11 between ERBB2 amplified GC tissues (Amp) (n = 55) and ERBB2 non-amplified GC tissues (Diploid) (n = 238) from TCGA dataset. (B) Correlation among mRNA expression (z-score) of CXCL9, CXCL10, CXCL11, CHEK1, CHEK2, and TP53 in samples from 412 patients with GC from TCGA dataset. (C) qPCR analysis of CXCL9, CXCL10, and CXCL11 in NCI-N87 cells treated with 1 μg/ml T-DXd in the absence or presence of 10 μM KU-55933 (KU), 10 μM VE-821 (VE), or 100 nM UCN-01 (UCN) for 72 h (n = 3). Values are shown as means ± SEM. *P < 0.05, **P < 0.01, ****P < 0.0001.