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. 2021 Aug 19;4:991. doi: 10.1038/s42003-021-02516-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The de novo purine biosynthesis pathway is illustrated with blue arrows. Other enzymes involved in purine and pyrimidine metabolism are shown with black arrows. Nucleoside uptake transporters are shown having dashed boxes. PurR is a transcriptional repressor of most of the purine biosynthesis and salvage genes in response to hypoxanthine and guanine. The PurR-regulated genes are highlighted in orange. The purine uptake transporter NupG is under transcriptional control of CytR, DeoR and CRP (shown in yellow). The purine transporter PunC (YdhC), described in this study, is controlled by the LysR-family activator PunR (YdhB) and Nac, as highlighted in green. Abbreviations: IMP, inosine monophosphate; AMP, adenosine monophosphate; GMP, guanosine monophosphate.