Figure 2.

Inhibition on P-gp doxorubicin (Dox) outward transport by different concentrations of compounds 5c (A) and 7b (B), determined by accumulation assay in Lucena 1 and (C) at 20 μM of both compounds in Lucena 1 and K562 cells. Doxorubicin-associated intracellular fluorescence significantly increased in Lucena 1 by treatments with selected compounds but not in K562. Significant differences relative to the respective negative control were determined by using a paired one-tailed Student’s t test (***p < 0.001, **p < 0.01, *p < 0.05).