Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 19;6:310. doi: 10.1038/s41392-021-00723-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a In a salvage pathway nicotinamide ribose (NR) and/or nicotinamide (NAM) are converted to nicotinamide mononucleotide (NMN), which is the precursor of nicotinamide adenine dinucleotide (NAD⁺). NAD⁺ is involved in a spectrum of diseases. b Postmenopausal prediabetic women with overweight or obesity were treated with NMN or placebo for 10 weeks and muscle biopsies revealed, c increased muscle NAD⁺ turnover, insulin sensitivity, phosphorylation of mTOR and Akt, and a gene expression involving the PDGF-binding pathway in NMN-treated participants as compared to control. d Open questions, however, remain to fully assess the mechanism of NMN in mediating muscle insulin sensitivity. Furthermore, potential long-term side effects should be considered. The figure was generated with Biorender.com.