Table 3.
Changes in tumor volume and SUVmax in NEOSTAR patients with abnormal nodes post-therapy.
| NEOSTAR cohort | ||||||||
|---|---|---|---|---|---|---|---|---|
| Tumor volume (mL) | ||||||||
| NIF (n = 7) | No-NIF (n = 18) | NIF (n = 7) | No-NIF (n = 18) | |||||
| Pre-ICIs | Post-ICIs | Pre-ICIs | Post-ICIs | Change (Post–Pre) | Change (Post–Pre) | |||
| Mean (SD) | Mean (SD) | P value | Mean (SD) | Mean (SD) | P value | Mean (SE) | Mean (SE) | P value |
| 23.8 (8.60) | 17.1 (13.7) | 0.496 | 49.0 (50.9) | 37.1 (44.5) | 0.059 | −6.67 (9.65) | −12.0 (6.02) | 0.089 |
| Tumor SUVmax | ||||||||
| NIF (n = 7) | No-NIF (n = 17)^ | NIF (n = 7) | No-NIF (n = 17)^ | |||||
| Pre-ICIs | Post-ICIs | Pre-ICIs | Post-ICIs | Change (Post–Pre) | Change (Post–Pre) | |||
| Mean (SD) | Mean (SD) | P value | Mean (SD) | Mean (SD) | P value | Mean (SE) | Mean (SE) | P value |
| 10.4 (4.40) | 8.98 (6.56) | 0.643 | 14.4 (6.93) | 14.7 (9.05) | 0.867 | −1.39 (2.95) | 0.32 (1.89) | 0.142 |
n, Number of patients. NIF nodal immune flare, SD standard deviation, SE standard error. ^One patient did not have post-ICI PET/CT images. SUVmax, maximum standardized uptake value. Two-sided P value is from linear mixed-effects model for tumor size and tumor SUVmax comparisons. Source data are provided as a Source Data file.