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. 2021 Aug 19;7:217. doi: 10.1038/s41420-021-00585-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A A PrimeView Human Gene Expression Array was conducted to distinguish the differentially expressed genes (DEGs) of SK-HEP-1 cells with or without silencing PSMC2. B A PSMC2-induced interaction network was established based on IPA analysis. Line: interaction; arrow: regulation; full line: direct regulation; dotted line: indirect regulation; green: downregulation; blue: predicted inhibition; white: with state of downstream molecule. The expression of several selected DEGs in SK-HEP-1 cells with or without PSMC2 knockdown was detected via qPCR (C) and western blotting (D). E The ITGA6 expression in HCC tissues and normal tissues was evaluated by IHC analysis (scale bar = 100 μm). F The mRNA expression of PSMC2 in normal cell line HL-7702 and HCC cell lines including HCCLM3, SK-HEP-1, BEL-7404, SNU423, and Hep3B2.1-7 was detected by qPCR. G A co-IP assay was performed to show the direct interaction between PSMC2 and ITGA6. The representative images were selected from at least three independent experiments. Data were shown as mean ± SD. *P < 0.05, **P < 0.01.