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. 2021 Aug 19;11:16805. doi: 10.1038/s41598-021-96132-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Flowchart for the structural (left) and diffusion MRI processing (right). To quantify GM volume (left), WM lesions in the 3D-MPRAGE were segmented using 3D-FLAIR as a reference and a WM lesion-filling approach was applied (a). We parcellated both the cortical pial surface (b), and the cortical and subcortical GM regions, to obtain volumetric values in 76 regions. To calculate the diffusion metrics in each region (right), after performing the standard diffusion pre-processing steps (d) we obtained the mean diffusivity and fractional anisotropy measures (e), which was realigned to the cortical and subcortical surface on the diffusion tensor imaging space (f).