Fig. 4.

Meprins are involved in granulation tissue formation and dermal healing. A, 7-day wounds stained for α-smooth actin (αSMA) (red) and 7- and 14-day wounds stained for fibronectin (green). Asterisks indicate non-specific staining of the scab. Nuclei were counterstained with DAPI (blue). Scale bar top panels for αSMA and fibronectin = 200 μm, mid and bottom panels for αSMA and fibronectin = 50 μm. B, Hematoxylin & eosin staining of sections from the middle of healing wounds 35 days after wounding. Scale bars = 200 μm. C, Bar graph showing quantification of dermal thickness in 35-day wounds. N = 3–4 wounds per genotype, values represent mean ± S.D. *P < 0.05; ***P < 0.001 as analyzed by one-way ANOVA with Tukey’s correction. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)