Fig. 5.

Altered appearance of the dermal collagen matrix in healing single meprin deficient wounds. A, Low power transmission electron microscopy images of 35-day wounds. Note the looser and less connected arrangement of collagen bundles in single meprin deficient wounds. Scale bar = 500 nm. B, Higher power magnification of dermal collagen fibrils in wounds described in A. Scale bar = 100 nm. C, Graphs shows quantification of the diameter of dermal collagen fibrils in wounds described in A. Indicated in the graph are median, 25th and 75th percentiles. **P < 0.01; ***P < 0.001; ****P < 0.0001 as analyzed by one-way ANOVA with Tukey’s correction.