Table 1.

Model performance statistics for survival prediction task and IDH mutation prediction task, evaluated among patients with grade 2 gliomas.

Survival prediction performance: C-index [95% CI]
	Without WSI risk score	With WSI risk score	Difference
None	–	0.715 [0.569, 0.830]	–
Age	0.745 [0.627, 0.838]	0.765 [0.643, 0.865]	0.020 [− 0.091, 0.100]
Gender	0.509 [0.345, 0.630]	0.688 [0.528, 0.815]	0.179 [− 0.007, 0.352]
Race	0.520 [0.444, 0.554]	0.713 [0.568, 0.831]	0.193 [0.056, 0.322]*
Primary diagnosis	0.572 [0.437, 0.707]	0.689 [0.539, 0.822]	0.117 [0.003, 0.230]*
IDH mutations	0.692 [0.573, 0.807]	0.762 [0.602, 0.878]	0.070 [− 0.048, 0.161]
Age + IDH mutations	0.774 [0.658, 0.863]	0.784 [0.655, 0.880]	0.010 [− 0.097, 0.085]

IDH mutation prediction performance: AUC [95% CI]
	Without WSI Predicted IDH Mutation Probability	With WSI Predicted IDH Mutation Probability	Difference
None	–	0.667 [0.532, 0.784]	–
Age	0.689 [0.552, 0.816]	0.726 [0.599, 0.845]	0.037 [− 0.053, 0.097]
Gender	0.536 [0.430, 0.643]	0.650 [0.507, 0.769]	0.114 [− 0.078, 0.240]
Race	0.567 [0.480, 0.650]	0.687 [0.560, 0.800]	0.120 [− 0.002, 0.229]
Primary diagnosis	0.519 [0.389, 0.641]	0.637 [0.472, 0.755]	0.118 [− 0.090, 0.261]
Age + Race	0.711 [0.585, 0.834]	0.739 [0.613, 0.856]	0.028 [− 0.051, 0.078]

95% confidence intervals were derived from 10,000 bootstrapping replications. Bold texts indicate the best performance for each column. * Indicates statistically significant difference (p < 0.05).