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. 2021 Aug 19;11:16839. doi: 10.1038/s41598-021-96107-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increased vitreal intensity after “post-blast” siCASP2 intravitreal injections, but no changes in retinal thickness and ED1⁺ cells in the ON after b-ITON. (A) Representative OCT scans. (B) There were no difference in GCC thickness between any groups (P = 0.121, ANOVA). (C) Vitreous intensity normalised to RPE intensity increased after b-ITON with siEGFP and siCASP2 intravitreal injections compared to b-ITON with no injections (P = 0.001, GEE) and in eyes receiving siCASP2 injections compared to siEGFP injections (P = 0.002, post-hoc Tukey). (D) There were no differences in total retinal thickness between any groups (P = 0.1012, ANOVA). (E) Representative ON immunofluorescent images stained for DAPI (blue) and ED1 (red). (F) ED1⁺ cells infiltrate the ON after b-ITON and with “post-blast” injections, although ED1⁺ cell counts did not reach significance (P = 0.23, ANOVA). Scale bar for (E) = 100 μm. Error bars represent mean ± SEM.