. 2021 Aug 8;12(3):506–513. doi: 10.1016/j.jaim.2021.05.005

Table 2.

Effect of EmbliQur and metformin on HOMA-IR and QUICKI in HFD/STZ-treated rats.

Day of study	Index type	Normal Control	HFD + STZ	EmbliQur 500	EmbliQur 1000	Metformin
Day 18 of the study and 1st day of drug treatment	HOMA-IR	3.78 ± 0.32	34.16 ± 5.17^$	33.75 ± 4.06	37.86 ± 6.60	31.70 ± 4.75
Day 18 of the study and 1st day of drug treatment	QUICKI	0.31 ± 0.01	0.24 ± 0.01^$	0.24 ± 0.01	0.24 ± 0.01	0.24 ± 0.01
Day 25 of study and 8th day of drug treatment	HOMA-IR	3.50 ± 0.28	31.33 ± 5.62^$	12.18 ± 1.20∗∗∗	17.70 ± 2.05∗	9.91 ± 0.69∗∗∗
Day 25 of study and 8th day of drug treatment	QUICKI	0.31 ± 0.0034	0.24 ± 0.0054^$	0.27 ± 0.0033∗∗∗	0.26 ± 0.0036∗∗∗	0.276 ± 0.0021∗∗∗
Day 32 of study and 15^thday of drug treatment	HOMA-IR	4.41 ± 0.41	35.36 ± 5.08^$	22.66 ± 4.90	19.43 ± 2.46∗	15.80 ± 2.76∗∗
Day 32 of study and 15^thday of drug treatment	QUICKI	0.31 ± 0.0036	0.24 ± 0.0049^$	0.25 ± 0.0055	0.25 ± 0.0033	0.26 ± 0.0042∗∗
Day 39 of the study and 22nd day of drug treatment	HOMA-IR	3.78 ± 0.17	32.18 ± 8.49^$	12.76 ± 0.45∗	6.81 ± 1.12∗∗∗	10.56 ± 1.70∗∗
Day 39 of the study and 22nd day of drug treatment	QUICKI	0.31 ± 0.01	0.24 ± 0.01^$	0.27 ± 0.00∗∗	0.29 ± 0.01∗∗∗	0.27 ± 0.01∗∗∗
Day 46 of the study and last day of drug treatment	HOMA-IR	4.63 ± 0.25	38.76 ± 2.20^$	6.23 ± 0.60∗∗∗	5.23 ± 0.38∗∗∗	5.81 ± 0.39∗∗∗
Day 46 of the study and last day of drug treatment	QUICKI	0.30 ± 0.01	0.238 ± 0.01^$	0.29 ± 0.01∗∗∗	0.30 ± 0.01∗∗∗	0.29 ± 0.01∗∗∗

All values are expressed as mean ± SEM; N = 6 in each group; One way ANOVA followed by Tukey–Kramer multiple comparison test is applied for statistical analysis; ^$p < 0.001when HFD/STZ group compared with Normal Control and ∗∗p < 0.01 and ∗∗∗p < 0.001 when experimental groups compared with HFD/STZ group.