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Assessment of Clostridium sordellii lethal toxin (LT) toxicity. The main characteristic of LT toxicity is increased vascular permeability with perivascular edema. Representative HE stainings of heart and lung tissue from mice treated with vehicle or a therapeutic dose of LT for 4 weeks show no signs of tissue edema. In contrast, mice that received a lethal dose of LT display edema in the connective tissue surrounding larger arteries (arrow heads).
