Table 3.

Characteristics of hyaluronic acid dermal fillers assessed in the analysis.

Product name	Concentration	Composition	References	Source of information
Belotero intense lidocaine	25 mg/ml	Cross-linked	Fischer et al. (55)	(75)
Emervel (range of products)	20 mg/ml	Cross-linked to various degree	Rzany et al. (57)	(57)
Hyamax Kiss	22 mg/ml	500 μm particle size, cross-linked	Yazdanparast et al. (50)	(50)
Juvéderm Ultra	24 mg/mil (0.3% Lidocaine)	Cross-linked (6%)	Fagien et al. (48); Carruthers et al. (52)	(48, 54)
Juvéderm Ultra XC (HYC-24L)	24 mg/mil (0.3% Lidocaine)	Cross-linked	Dayan et al. (42); Bulam et al. (60)	(42)
Juvéderm Volbella without Lidocaine	15 mg/ml	Not available	Eccleston et al. (47); Artzi et al. (53)	(47)
Juvéderm Volbella with Lidocaine	15 mg/ml HA (0.3% Lidocaine)	Cross-linked	Raspaldo et al. (45); Philipp-Dormston et al. (56)	(45, 76)
Juvéderm Volbella XC (VYC-15L)	15 mg/ml HA (0.3% Lidocaine)	Cross-linked, low- and high-molecular-weight HA	Geronemus et al. (43)	(77)
Perlane	20 mg/ml	Cross-linked, 1,000 μm particle size	Downie et al. (51)	(51, 78)
Restylane (without lidocaine)	Not available	SGP, 300 μm particle size, cross-linked	Glogau et al. (44); Solish and Swift (49); Carruthers et al. (54); Fernández-Aceñero Ma et al. (68); Anatelli et al. (59); Curi et al. (61); Dougherty et al. (62); Leonhardt et al. (70); Wolfram et al. (72); Farahani et al. (66); Edwards et al. (64)	(44, 49)
Restylane-L	20 mg/ml HA (0.3% Lidocaine)	SGP, cross-linked	Raspaldo et al. (45); Geronemus et al. (43); Beer et al. (41); Chopra et al. (46)	(41, 43, 45, 46, 79)
Restylane lip volume	20 mg/ml HA (0.3% Lidocaine)	Cross-linked	Samuelson et al. (58)	(58)
HA not further specified	N/A	N/A	Duhovic and Duarte-Williamson (63); Eversole et al. (65); Feio et al. (67); Grippaudo et al. (69); Martin et al. (71)	N/A

N/A, not applicable; HA, hyaluronic acid.