Table 5.
Papers on breast cancer.
| Authors | Study group | Methodology | Diagnosis | Prognosis | Survival |
|---|---|---|---|---|---|
| Kruger et al59 | 5 pts series with primary invasive breast carcinoma: series I (n = 546), series II (n = 282), series III (n = 98), series IV (n = 192), series V (n = 35) | IHC | Nestin was strongly associated with germline BRCA1 related breast cancer | – | Nestin protein positivity was independently associated with reduced breast cancer specific survival |
| Tampaki et al60 | 141 radically operated pts with breast cancer | IHC | – | Nestin is expressed in breast cancer cells with highly aggressive potency | When nestin is expressed, a significantly higher disease recurrence exists |
| Parry et al61 | 245 invasive breast cancer | IHC | – | Nestin was an independent prognostic factor | Nestin was not associated with disease-free, metastasis-free or breast cancer specific survival |
| Rogelsperger et al62 | 42 patients with primary breast cancer | Double immunofluorescence staining | – | The co-expression of melatonin receptor-1 with nestin in breast cancer cells invading the stroma was associated with a more advanced tumor stage and worse prognosis | – |
| Piras et al63 | 53 pts with T4 breast cancer (stage IIIB) |
IHC | – | The presence of nestin in tumoral cells significantly predicted poor prognosis at 5 year survival | |
| Gao et al64 | 109 pts with breast cancer who underwent radical operations |
IHC | – | The expression of nestin might play an important role in the prognosis of breast carcinoma | Nestin may have an important effect on the development and metastasis in breast carcinoma |
Abbreviations: BRCA, breast cancer; IHC, immunohistochemistry.