Figure 4.

Associations between different AT(N) combinations and longitudinal cognition in the CU group. Marginal R² for different AT(N) variants to predict longitudinal clinical dementia rating sum of boxes (CDRSB) and mini-mental state examination (MMSE) for cognitively unimpaired (CU), respectively (divided by A biomarkers) (A,D). The selected models in (B,C) and (E,F) are the top two best models for different cognitive scales. The LME models with significant AT(N) biomarkers to predict longitudinal are CDRSB and MMSE, respectively (G,H); AT(N) variants chosen in the model, p-values, and marginal R² are shown at the top (CDRSB) or bottom (MMSE) of each panel; 25 and 75 refer to 25th and 75th quartiles, where a lower value indicates a more abnormal biomarker. Aβ, β-amyloid; AT(N), β-amyloid, tau, and neurodegeneration classification system; ITC, inferior temporal cortex; p-tau, tau phosphorylated at Thr181; ROI, region of interest; SUVR, standardized uptake value ratio.