Figure 5.

Associations between different AT(N) combinations and longitudinal cognition in the CI group. Marginal R² for different AT(N) variants to predict longitudinal clinical dementia rating sum of boxes (CDRSB) and mini-mental state examination (MMSE) for cognitively impaired (CI), respectively (divided by A biomarkers) (A,D). The selected models in (B,C) and (E,F) are the top two best models for the different cognitive scales. The top two best models with an interaction between time and AT(N) variants to predict longitudinal CDRSB and MMSE, respectively (G–J); AT(N) variants chosen in the model and p-values, and marginal R² are shown at the top (CDRSB) or bottom (MMSE) of each panel; 25 and 75 refer to 25th and 75th quartiles, where a lower value indicates a more abnormal biomarker. Aβ, β-amyloid; AT(N), β-amyloid, tau, and neurodegeneration classification system; ITC, inferior temporal cortex; ROI, region of interest; SUVR, standardized uptake value ratio.