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. 2021 Aug 6;11:712348. doi: 10.3389/fonc.2021.712348

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Copyright © 2021 Zhuang, Sun, Chong, Banerjee, Zhang, Wu, Zhu, Pandey and Lobie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased expression of ARTN in CRC is associated with poor prognosis. (A) Immunohistochemical analysis of ARTN protein expression in non-cancerous colorectal tissue (left) and colorectal carcinoma tissue (right). Original images were taken at the magnification of X200 under a microscope. The indicated areas (red rectangular) were enlarged for staining details. The red arrowheads indicate the positive staining for ARTN. (B) Kaplan–Meier analysis of the correlation of the immunohistochemistry-determined ARTN protein expression to relapse-free survival (left) and overall survival (right) of colorectal carcinoma patients. Data were collected from 42 out of 89 colorectal carcinoma cases.