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. 2021 Aug 6;9:705302. doi: 10.3389/fcell.2021.705302

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Copyright © 2021 Kong, Dong, Xu, Fan, Miao, Guo, Li, Ye, Wang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Choline kinase alpha expression correlates with Brg1 expression in ALF patients. (A) Paraffin sections of liver specimens collected from patients with acute liver failure were stained with anti-CHKA and anti-Brg1. N = 8 cases. (B) Linear regression was performed with GraphPad Prism. (C) A schematic model. Under physiological conditions, HIF-1α proteins are constantly degraded in hepatocytes presumably by the ubiquitin–proteasome system and Chka transcription is turned off. Exposed to injurious stimuli, HIF-1α proteins become stabilized and recruit BRG1 to activate Chka transcription. Elevated Chka levels may alter cellular metabolism and promote proliferation of hepatocytes eventually leading to liver regeneration.