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. 2021 Aug 12;46(4):218. doi: 10.3892/or.2021.8169

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — circNRIP1 attenuates the sensitivity of CRC cells to 5-FU via regulating the expression of miR-532-3p. (A and B) Effect of cell co-transfection with si-cNRIP1 and miR-532-3p inhibitor on the proliferation of (A) HCT116 and (B) SW480 cells. (C-E) Influence of co-transfection with si-cNRIP1 and miR-532-3p inhibitor on the effect of 5-FU on CRC cells. (C) Apoptosis of CRC cells and viability of (D) HCT116 and (E) SW480 cells treated with increasing concentrations of 5-FU. *P<0.05, **P<0.01 and ***P<0.001 vs. the si-cNRIP1 + miR-NC group. circ-NRIP1, circRNA nuclear receptor-interacting protein 1; CRC, colorectal cancer; miR-532-3p, microRNA-532-3p; 5-FU, 5-fluorouracil; si, small interfering RNA; IC₅₀, half maximal inhibitory concentration; NC, negative control; OD, optical density; PI, propidium iodide; Q, quadrant; LR, lower right; LL, lower left; UL, upper left; UR, upper right.