Table 2.
Cox Regression for Thyrotropin-Binding Inhibitory Immunoglobulin Reduction
| Group | Total thyroidectomy |
Radioiodine therapy |
||||
|---|---|---|---|---|---|---|
| HR | [CI] | p | HR | [CI] | p | |
| Univariable analysis | ||||||
| Age, years | 0.95 | [0.91–0.98] | <0.01 | 1.00 | [0.98–1.03] | 0.77 |
| Goitera | ||||||
| Grade 0 (reference) | 1.00 | 1.00 | ||||
| Grade 1 | 0.74 | [0.11–4.90] | >0.99 | 0.69 | [0.30–1.60] | 0.65 |
| Grade 2 | 0.72 | [0.13–3.87] | >0.99 | 0.10 | [0.01–0.94] | 0.04 |
| Quartiles of pretreatment TBIIa | ||||||
| Q1 (reference) | 1.00 | 1.00 | ||||
| Q2 | 0.26 | [0.07–0.99] | 0.05 | 1.27 | [0.41–3.96] | >0.99 |
| Q3 | 0.16 | [0.04–0.68] | <0.01 | 1.33 | [0.45–3.94] | >0.99 |
| Q4 | 0.32 | [0.10–1.09] | 0.08 | 0.23 | [0.04–1.48] | 0.17 |
| Quartiles of the ATD durationa | ||||||
| Q1 (reference) | 1.00 | 1.00 | ||||
| Q2 | 0.66 | [0.15–2.83] | >0.99 | 1.14 | [0.42–3.12] | >0.99 |
| Q3 | 1.00 | [0.26–3.86] | >0.99 | 0.54 | [0.15–1.94] | 0.74 |
| Q4 | 0.76 | [0.21–2.80] | >0.99 | 0.51 | [0.15–1.71] | 0.54 |
| Multivariable analysis | ||||||
| Age, years | 0.94 | [0.89–0.98] | <0.01 | 0.99 | [0.96–1.02] | 0.50 |
| Goitera | ||||||
| Grade 0 (reference) | 1.00 | 1.00 | ||||
| Grade 1 | 0.37 | [0.03–4.07] | 0.71 | 0.64 | [0.23–1.77] | 0.65 |
| Grade 2 | 0.56 | [0.05–6.29] | >0.99 | 0.12 | [0.01–1.44] | 0.11 |
| Quartiles of pretreatment TBIIa | ||||||
| Q1 (reference) | 1.00 | 1.00 | ||||
| Q2 | 0.20 | [0.04–0.90] | 0.03 | 0.20 | [1.36–3.96] | >0.99 |
| Q3 | 0.15 | [0.03–0.85] | 0.03 | 1.25 | [0.40–3.90] | >0.99 |
| Q4 | 0.19 | [0.04–0.87] | 0.03 | 0.33 | [0.05–2.29] | 0.52 |
| Quartiles of the ATD durationa | ||||||
| Q1 (reference) | 1.00 | 1.00 | ||||
| Q2 | 0.73 | 0.12–4.59 | >0.99 | 1.36 | [0.48–3.83] | >0.99 |
| Q3 | 0.99 | 0.13–7.36 | >0.99 | 1.01 | [0.23–4.40] | >0.99 |
| Q4 | 0.95 | 0.18–4.90 | >0.99 | 0.59 | [0.17–2.08] | 0.94 |
a
For these categorical variables, multiple comparison with Bonferroni's method was used to correct the p-value and confidence interval.
CI, confidence interval; HR, hazard ratio; Q, quartile group of continuous variables.