Table 5.

Plasma Vardenafil Pharmacokinetic Parameters After Administration of Single Doses of Vardenafil as 0.6 mg Inhaled RT234 and 20 mg Oral Levitra Tablets to Healthy Subjects

Treatment	Mean (CV%) plasma vardenafil pharmacokinetic parameter values
	tmaxa (h)	Cmax (ng/mL)	AUC(0–last) (h · ng/mL)	AUC(0–inf) (h · ng/mL)
0.6 mg RT234 (N = 5)	0.03	3.178 (65)	4.052 (18)	4.348 (18)
20 mg oral Levitra (N = 5)	0.75	21.16 (30)	53.15 (29)	54.36 (29)
20 mg oral Levitra/0.6 mg RT234	25	6.7	13.1	12.5
	Mean (CV%) plasma vardenafil bioavailability parameter values after administration of 2.4 mg RT234
		Cmax (ng/mL)	AUC(0–last) (h · ng/mL)	AUC(0–inf) (h · ng/mL)
2.4 mg RT234 (N = 6)		8.467 (40)	18.2 (15)	18.67 (14)
20 mg oral Levitra/2.4 mg RT234		2.5	2.9	2.9

^aMedian t_max displayed.