Table 6.

Plasma Vardenafil Pharmacokinetic Parameters by Day and Dose Number

Day and dose number	Mean (95% CIa) plasma vardenafil pharmacokinetic parameters
	tmaxb (h)	Cmax (ng/mL)	AUC(0–4) (h · ng/mL)	AUC(0–last) (h · ng/mL)	AUC(0–inf) (h · ng/mL)
Day 1, dose 1	0.090	21.44	12.62	ND	ND
		(16.76–29.59)	(10.85–15.62)
Day 1, dose 2	0.075	18.92	15.32	21.32	21.85
		(15.24–23.44)	(13.37–18.33)	(18.87–24.97)	(19.29–25.63)
Day 2, dose 3	0.080	15.58	16.02	22.58	23.54
		(12.40–18.85)	(13.97–18.68)	(20.54–25.51)	(20.87–27.51)
Day 9, dose 4	0.080	14.52	15.43	23.69	25.29
		(11.64–21.18)	(13.40–19.76)	(20.24–31.64)	(21.95–32.67)

^aBias-corrected Bayesian bootstrap CI.

^bMedian t_max from observed values.

ND, not determined; CI, confidence interval.