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Percent of N-acetylgalactosamine-Conjugated Small Interfering RNA Bound to Proteins in Varying Concentrations of Fetal Bovine or Human Serum
| GalNAc-conjugated siRNA | Serum | 20% | 40% | 60% | 80% | 100% |
|---|---|---|---|---|---|---|
| AD-60519 | Bovine | 11.7 ± 7.0 | 58.4 ± 6.9 | 71.4 ± 3.4 | 75.4 ± 1.8 | 81.8 ± 2.8 |
| AD-65644 | Human | NT | NT | 65.5 ± 1.2 | NT | NT |
| AD-64543 | Human | NT | NT | 71.8 ± 0.6 | NT | NT |
NT, not tested.
