Table 1. Association of Body Size, Body Fat Distribution, and Body Composition With All-Cause and Breast Cancer–Specific Mortality Among Black Breast Cancer Survivors.
| Variable | Participants, No./total No. (%) | All-cause mortality | Breast cancer–specific mortality | ||||
|---|---|---|---|---|---|---|---|
| Total deaths | HR (95% CI)a | P value for trend | Deaths associated with breast cancer | HR (95% CI)b | P value for trend | ||
| Baseline BMI | |||||||
| Normal (18.5-24.9) | 301/1889 (15.9) | 47 | 1 [Reference] | .12 | 28 | 1 [Reference] | .12 |
| Overweight (25.0-29.9) | 528/1889 (28.0) | 64 | 0.94 (0.64-1.37) | 40 | 0.93 (0.57-1.53) | ||
| Obese class 1 (30.0-34.9) | 501/1889 (26.5) | 75 | 1.17 (0.80-1.67) | 48 | 1.27 (0.80-2.03) | ||
| Obese class 2-3 (≥35.0) | 559/1889 (29.6) | 100 | 1.26 (0.89-1.79) | 59 | 1.33 (0.84-2.10) | ||
| Per 5.0 U | 1889/1889 (100) | 286 | 1.11 (1.02-1.20) | NA | 175 | 1.11 (1.00-1.23) | NA |
| Waist circumference, cm | |||||||
| Quartile 1 (≤90.5) | 458/1857 (24.7) | 60 | 1 [Reference] | .19 | 39 | 1 [Reference] | .19 |
| Quartile 2 (90.6-100.1) | 465/1857 (25.0) | 47 | 0.91 (0.62-1.33) | 28 | 0.79 (0.48-1.32) | ||
| Quartile 3 (100.2-110.9) | 466/1857 (25.1) | 60 | 1.00 (0.69-1.44) | 40 | 1.03 (0.65-1.63) | ||
| Quartile 4 (>110.9) | 468/1857 (25.2) | 107 | 1.74 (1.26-2.41) | 61 | 1.64 (1.08-2.48) | ||
| Per 10.0 cm | 1857/1857 (100) | 274 | 1.14 (1.06-1.23) | NA | 168 | 1.11 (1.01-1.22) | NA |
| Waist-to-hip ratio | |||||||
| Quartile 1 (0.65-0.84) | 461/1857 (24.8) | 48 | 1 [Reference] | .03 | 28 | 1 [Reference] | .03 |
| Quartile 2 (0.85-0.89) | 464/1857 (25.0) | 59 | 1.07 (0.73-1.58) | 39 | 1.25 (0.75-2.07) | ||
| Quartile 3 (0.90-0.95) | 467/1857 (25.1) | 73 | 1.37 (0.94-2.00) | 47 | 1.47 (0.88-2.46) | ||
| Quartile 4 (>0.95) | 465/1857 (25.1) | 94 | 1.61 (1.12-2.33) | 54 | 1.68 (1.04-2.71) | ||
| Per 0.10 U | 1857/1857 (100) | 274 | 1.29 (1.11-1.50) | NA | 168 | 1.19 (0.99-1.44) | NA |
| Body fat, % | |||||||
| Quartile 1 (<37.1) | 440/1765 (24.9) | 61 | 1 [Reference] | .16 | 35 | 1 [Reference] | .16 |
| Quartile 2 (37.1-41.9) | 435/1765 (24.6) | 56 | 1.14 (0.79-1.65) | 38 | 1.29 (0.80-2.08) | ||
| Quartile 3 (42.0-46.5) | 447/1765 (25.3) | 58 | 1.08 (0.75-1.56) | 33 | 1.12 (0.68-1.85) | ||
| Quartile 4 (>46.5) | 443/1765 (25.1) | 82 | 1.53 (1.09-2.15) | 52 | 1.81 (1.17-2.80) | ||
| Per 5.0 U | 1765/1765 (100) | 257 | 1.10 (1.01-1.20) | NA | 158 | 1.13 (1.00-1.28) | NA |
| FMI | |||||||
| Quartile 1 (<9.9) | 435/1764 (24.7) | 55 | 1 [Reference] | .04 | 33 | 1 [Reference] | .03 |
| Quartile 2 (9.9-12.8) | 444/1764 (25.2) | 63 | 1.22 (0.85-1.75) | 41 | 1.27 (0.79-2.03) | ||
| Quartile 3 (12.9-16.5) | 442/1764 (25.0) | 61 | 1.22 (0.85-1.77) | 35 | 1.28 (0.79-2.09) | ||
| Quartile 4 (>16.5) | 443/1764 (25.1) | 79 | 1.57 (1.11-2.22) | 50 | 1.74 (1.10-2.75) | ||
| Per 5.0 U | 1764/1764 (100) | 258 | 1.18 (1.05-1.33) | NA | 159 | 1.20 (1.02-1.41) | NA |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); FMI, fat mass index (calculated as fat mass in kilograms divided by height in meters squared); HR, hazard ratio; NA, not applicable.
a
Hazard ratios and 95% CIs from Cox proportional hazards model were adjusted for age, income, smoking status, tumor stage, tumor subtype, and type of surgery.
b
Hazard ratios and 95% CIs from Fine and Gray subdistribution hazard model25 were adjusted for age, income, smoking status, tumor stage, tumor subtype, and type of surgery.