Table 2. Association of Body Size, Body Fat Distribution, and Body Composition With All-Cause Mortality by Estrogen Receptor Status Among Black Breast Cancer Survivors.
| Variable | Estrogen receptor–positive | Estrogen receptor–negative | P value for interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Participants, No./total No. (%) | Total deaths | HR (95% CI)a | P value for trend | Participants, No./total No. (%) | Total deaths | HR (95% CI)a | P value for trend | ||
| Baseline BMI | |||||||||
| Normal (18.5-24.9) | 200/1332 (15.0) | 28 | 1 [Reference] | .12 | 93/506 (18.4) | 18 | 1 [Reference] | .11 | .91 |
| Overweight (25.0-29.9) | 372/1332 (27.9) | 38 | 0.93 (0.57-1.53) | 140/506 (27.7) | 25 | 0.92 (0.50-1.71) | |||
| Obese class 1 (30.0-34.9) | 347/1332 (26.1) | 45 | 1.02 (0.63-1.65) | 136/506 (26.9) | 28 | 1.23 (0.67-2.24) | |||
| Obese class 2-3 (≥35.0) | 413/1332 (31.0) | 65 | 1.20 (0.76-1.90) | 137/506 (27.1) | 35 | 1.34 (0.75-2.42) | |||
| Per 5.0 U | 1332/1332 (100) | 176 | 1.12 (1.02-1.24) | NA | 506/506 (100) | 106 | 1.11 (0.96-1.27) | NA | .87 |
| Waist circumference, cm | |||||||||
| Quartile 1 (<90.6) | 309/1314 (23.5) | 37 | 1 [Reference] | .18 | 139/495 (28.1) | 22 | 1 [Reference] | .20 | .36 |
| Quartile 2 (90.6-100.1) | 328/1314 (25.0) | 26 | 0.74 (0.44-1.24) | 116/495 (23.4) | 19 | 1.09 (0.59-2.04) | |||
| Quartile 3 (100.2-110.9) | 334/1314 (25.4) | 36 | 0.88 (0.55-1.40) | 123/495 (24.8) | 24 | 1.26 (0.70-2.28) | |||
| Quartile 4 (>110.9) | 343/1314 (26.1) | 68 | 1.57 (1.03-2.39) | 117/495 (23.6) | 38 | 1.90 (1.10-3.29) | |||
| Per 10.0 cm | 1314/1314 (100) | 167 | 1.16 (1.06-1.28) | NA | 495/495 (100) | 103 | 1.12 (0.99-1.27) | NA | .53 |
| Waist-to-hip ratio | |||||||||
| Quartile 1 (0.65-0.84) | 331/1314 (25.2) | 34 | 1 [Reference] | .03 | 120/495 (24.2) | 13 | 1 [Reference] | .02 | .36 |
| Quartile 2 (0.85-0.89) | 319/1314 (24.3) | 34 | 0.83 (0.51-1.35) | 130/495 (26.3) | 25 | 1.81 (0.92-3.57) | |||
| Quartile 3 (0.90-0.95) | 330/1314 (25.1) | 40 | 1.10 (0.69-1.77) | 126/495 (25.5) | 31 | 2.14 (1.09-4.19) | |||
| Quartile 4 (>0.95) | 334/1314 (25.4) | 59 | 1.38 (0.89-2.15) | 119/495 (24.0) | 34 | 2.24 (1.14-4.41) | |||
| Per 0.10 U | 1314/1314 (100) | 167 | 1.29 (1.06-1.57) | NA | 495/495 (100) | 103 | 1.31 (1.03-1.66) | NA | .90 |
| Body fat, % | |||||||||
| Quartile 1 (<37.1) | 293/1247 (23.5) | 37 | 1 [Reference] | .16 | 132/477 (27.7) | 23 | 1 [Reference] | .16 | .16 |
| Quartile 2 (37.1-41.9) | 311/1247 (24.9) | 35 | 1.19 (0.74-1.91) | 114/477 (23.9) | 21 | 1.05 (0.57-1.93) | |||
| Quartile 3 (42.0-46.5) | 322/1247 (25.8) | 36 | 1.04 (0.65-1.66) | 115/477 (24.1) | 22 | 1.34 (0.74-2.44) | |||
| Quartile 4 (>46.5) | 321/1247 (25.7) | 50 | 1.52 (0.98-2.35) | 116/477 (24.3) | 31 | 1.78 (1.03-3.09) | |||
| Per 5.0 U | 1247/1247 (100) | 158 | 1.09 (0.97-1.22) | NA | 477/477 (100) | 97 | 1.17 (1.02-1.34) | NA | .34 |
| FMI | |||||||||
| Quartile 1 (<9.9) | 294/1247 (23.6) | 35 | 1 [Reference] | .03 | 129/476 (27.1) | 19 | 1 [Reference] | .04 | .41 |
| Quartile 2 (9.9-12.8) | 314/1247 (25.2) | 36 | 1.18 (0.73-1.89) | 119/476 (25.0) | 27 | 1.38 (0.75-2.53) | |||
| Quartile 3 (12.9-16.5) | 316/1247 (25.3) | 38 | 1.06 (0.66-1.69) | 113/476 (23.7) | 23 | 1.79 (0.97-3.33) | |||
| Quartile 4 (>16.5) | 323/1247 (25.9) | 50 | 1.54 (0.98-2.41) | 115/476 (24.2) | 28 | 1.78 (0.99-3.23) | |||
| Per 5.0 U | 1247/1247 (100) | 159 | 1.19 (1.02-1.39) | NA | 476/476 (100) | 97 | 1.23 (1.01-1.49) | NA | .79 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); FMI, fat mass index (calculated as fat mass in kilograms divided by height in meters squared); HR, hazard ratio; NA, not applicable.
a
Hazard ratios and 95% CIs were adjusted for age, income, smoking status, tumor stage, and type of surgery.