Table 3. Association of Body Size, Body Fat Distribution, and Body Composition With All-Cause Mortality by Menopausal Status Among Black Breast Cancer Survivors.
| Variable | Premenopausal | Postmenopausal | P value for interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Participants, No./total No. (%) | Total deaths | HR (95% CI)a | P value for trend | Participants, No./total No. (%) | Total deaths | HR (95% CI)a | P value for trend | ||
| Baseline BMI | |||||||||
| Normal (18.5-24.9) | 140/730 (19.2) | 19 | 1 [Reference] | .11 | 161/1159 (13.9) | 28 | 1 [Reference] | .11 | .37 |
| Overweight (25.0-29.9) | 211/730 (28.9) | 22 | 0.69 (0.37-1.29) | 317/1159 (27.3) | 42 | 1.14 (0.70-1.85) | |||
| Obese class 1 (30.0-34.9) | 187/730 (25.6) | 29 | 1.03 (0.56-1.89) | 314/1159 (27.1) | 46 | 1.22 (0.76-1.97) | |||
| Obese class 2-3 (≥35.0) | 192/730 (26.3) | 35 | 1.33 (0.75-2.37) | 367/1159 (31.7) | 65 | 1.26 (0.80-1.99) | |||
| Per 5.0 U | 730/730 (100) | 105 | 1.13 (1.00-1.29) | NA | 1159/1159 (100) | 181 | 1.09 (0.99-1.21) | NA | .54 |
| Waist circumference, cm | |||||||||
| Quartile 1 (<90.6) | 236/718 (32.9) | 33 | 1 [Reference] | .17 | 222/1139 (19.5) | 27 | 1 [Reference] | .19 | .49 |
| Quartile 2 (90.6-100.1) | 169/718 (23.5) | 13 | 0.54 (0.28-1.03) | 296/1139 (26.0) | 34 | 1.31 (0.78-2.19) | |||
| Quartile 3 (100.2-110.9) | 162/718 (22.6) | 23 | 0.88 (0.50-1.52) | 304/1139 (26.7) | 37 | 1.14 (0.69-1.88) | |||
| Quartile 4 (>110.9) | 151/718 (21.0) | 33 | 1.55 (0.93-2.59) | 317/1139 (27.8) | 74 | 2.12 (1.35-3.31) | |||
| Per 10.0 cm | 718/718 (100) | 102 | 1.10 (0.98-1.24) | NA | 1139/1139 (100) | 172 | 1.17 (1.07-1.29) | NA | .49 |
| Waist-to-hip ratio | |||||||||
| Quartile 1 (0.65-0.84) | 261/718 (36.3) | 29 | 1 [Reference] | .03 | 200/1139 (17.6) | 19 | 1 [Reference] | .02 | .05 |
| Quartile 2 (0.85-0.89) | 173/718 (24.1) | 30 | 1.14 (0.67-1.96) | 291/1139 (25.5) | 29 | 0.99 (0.55-1.78) | |||
| Quartile 3 (0.90-0.95) | 167/718 (23.3) | 24 | 1.03 (0.58-1.82) | 300/1139 (26.3) | 49 | 1.82 (1.06-3.12) | |||
| Quartile 4 (>0.95) | 117/718 (16.3) | 19 | 1.02 (0.56-1.89 | 348/1139 (30.6) | 75 | 2.15 (1.28-3.61) | |||
| Per 0.10 U | 718/718 (100) | 102 | 1.03 (0.791.34) | NA | 1139/1139 (100) | 172 | 1.47 (1.22-1.77) | NA | .06 |
| Body fat, % | |||||||||
| Quartile 1 (<37.1) | 214/697 (30.7) | 26 | 1 [Reference] | .16 | 226/1068 (21.2) | 35 | 1 [Reference] | .16 | .37 |
| Quartile 2 (37.1-41.9) | 184/697 (26.4) | 26 | 1.11 (0.63-1.95) | 251/1068 (23.5) | 30 | 1.13 (0.68-1.87) | |||
| Quartile 3 (42.0-46.5) | 148/697 (21.2) | 16 | 0.86 (0.45-1.65) | 299/1068 (28.0) | 42 | 1.18 (0.74-1.87) | |||
| Quartile 4 (>46.5) | 151/697 (21.7) | 32 | 1.66 (0.97-2.86) | 292/1068 (27.3) | 50 | 1.45 (0.92-2.27) | |||
| Per 5.0 U | 697/697 (100) | 100 | 1.09 (0.95-1.25) | NA | 1068/1068 (100) | 157 | 1.11 (0.99-1.24) | NA | .91 |
| FMI | |||||||||
| Quartile 1 (<9.9) | 204/697 (29.3) | 23 | 1 [Reference] | .03 | 231/1067 (21.6) | 32 | 1 [Reference] | .04 | .56 |
| Quartile 2 (9.9-12.8) | 182/697 (26.1) | 25 | 1.21 (0.68-2.16) | 262/1067 (24.6) | 38 | 1.20 (0.74-1.92) | |||
| Quartile 3 (12.9-16.5) | 145/697 (20.8) | 20 | 1.23 (0.66-2.29) | 297/1067 (27.8) | 41 | 1.18 (0.74-1.89) | |||
| Quartile 4 (>16.5) | 166/697 (23.8) | 32 | 1.70 (0.98-2.95) | 277/1067 (26.0) | 47 | 1.44 (0.91-2.29) | |||
| Per 5.0 U | 697/697 (100) | 100 | 1.20 (0.99-1.45) | NA | 1067/1067 (100) | 158 | 1.16 (0.99-1.36) | NA | .72 |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); FMI, fat mass index (calculated as fat mass in kilograms divided by height in meters squared); HR, hazard ratio; NA, not applicable.
a
Hazard ratios and 95% CIs adjusted for age, income, smoking, tumor stage, tumor subtype, and type of surgery.