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. 2021 Aug 19;7(10):1–8. doi: 10.1001/jamaoncol.2021.2723

Figure 1. Association of Concomitant 22q11.22 Deletions With Survival Outcomes Among Patients With IKZF1 Alterations.

Figure 1.

A, Shown for each cohort are the unadjusted hazard ratios for the effect of 22q11.22 deletions on event-free survival (EFS) in persons having IKZF1 alterations. The combined row shows the overall hazard ratio for all persons from a proportional hazards model adjusted for the study cohorts. B, Shown for each cohort are the unadjusted hazard ratios for the association of 22q11.22 deletions with overall survival (OS) in persons having IKZF1 alterations. The combined row shows the overall hazard ratio for all persons from a proportional hazards model adjusted for the study cohorts. The Utah cohort not shown because of small numbers (7 patients with a 22q11.22 + IKZF1 double deletion, of whom 3 died and none had other events; 4 patients with an IKZF1 alteration and WT 22q11.22, of whom all patients survived and none had events). Overall survival data were not available for the Children’s Hospital of Philadelphia (CHOP) cohort. DS indicates Down syndrome; SJCRH, St. Jude Children’s Research Hospital.