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. Author manuscript; available in PMC: 2022 Jan 12.
Published in final edited form as: J Appl Lab Med. 2021 Jan 12;6(1):285–297. doi: 10.1093/jalm/jfaa196

Table 1.

Drugs Detected in Umbilical Cord Tissue Specimens.

Total n Overall, % Of drugs, % Epoch 1 n Overall, % Epoch 2 n Overall, % Epoch 1 vs 2 % Change, %
Total UCTDA orders 6051 3021 3030
Live births 6100 3063 3037
% Births with UCTDA 99.2 98.6 99.8
Positive specimensa 1357 22 753 25 604 20 −20
Opioidsb 279 5 42 91 3 188 6 +107
 Codeine 23 0.4 3.5 12 0.4 11 0.4 −8
 Dihydrocodeine 4 0.1 0.6 2 0.1 2 0.1 NC
 Hydrocodone 91 1.5 13.7 15 0.5 76 2.5 +407
 Meperidine 12 0.2 1.8 9 0.3 3 0.1 NC
 Heroin 6 0.1 0.9 4 0.1 2 0.1 NC
 Oxycodone and/or oxymorphone 110 1.8 16.5 25 0.8 85 2.8 +240
 Tramadol 33 0.5 5.0 24 0.8 9 0.3 −63
Stimulants 189 3 28 30 1 159 5 +430
 Amphetamines 113 1.8 17 16 0.6 97 3.2 +506
 Cocaine 74 1.2 11.1 12 0.4 62 2.0 +417
 Phentermine 2 <0.1 0.3 2 0.1 0 0.0 NC
Sedatives/Hypnotics 197 3 30 118 4 79 3 −33
 Alprazolam 27 0.4 4.1 11 0.4 16 0.5 +45
 Butalbital 14 0.2 2.1 11 0.4 3 0.1 −73
 Clonazepam 29 0.5 4.4 12 0.4 17 0.6 +42
 Diazepam 19 0.3 2.9 11 0.4 8 0.3 −27
 Lorazepam 3 <0.1 0.5 3 0.1 0 0.0 NC
 Midazolam 16 0.3 2.4 8 0.3 8 0.3 NC
 Phenobarbital 8 0.1 1.2 8 0.3 0 0.0 NC
 Temazepam 4 0.1 0.6 1 <0.1 3 0.1 NC
 Zolpidem 77 1.3 11.6 53 1.8 24 0.8 −55
Total drugs detecteda 665 239 426 +78

NC, no change.

a

Given the retrospective nature of data capture and categorization and the exclusion of THC from the report, the number of positive specimens and the total number of drugs detected are not equal.

b

Four opioids (FEN, MOR, BUP, and MTD) have been separated and summarized separately in Table 2 given common use for pain control in labor and delivery and SUD maintenance programs.